Selected Publications

Saadipour, K., Tibera, A., Lomardo, S., Grajales, E., Manucat-Tan, N.B., LaFrancois J., Cammer M., Mathews, P.M., Scharfman, H.E., Liao, F.F., Friedman, W.J., Zhou X.F., Tesco G., Chao M.V. (2019) Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor. Mol Cell Neurosci doi:10.1016/j.mcn.2019.103395l.

Saadipour, K., MacLean, M., Pirkle, S, Ali, S., Lopez-Redondo, M.L., Stokes, D.L., Chao, M.V. (2017) The transmembrane domain of the p75 neurotrophin receptor stimulates phosphorylation of the TrkB tyrosine kinase receptor. J Biol Chem 292, 16594-16604.

Mitre, M., Marlin, B.J., Schiavo, J.K., Morina, E., Norden, S., Hackett, T.A., Aoki, C.J., Chao, M.V., Froemke, R.C. (2016) A distributed network for social cognition enriched for oxytocin receptors. J Neuroscience 36, 2517.

Sleiman, S.F., Kessna-Henry, J., Al-Haddad, R., El Hayek, L., Haidar, E.A., Stringer, T., Ulja, D., Karuppagounder, S.S., Holson,   E.B., Ratan, R.R., Ninan, I. and Chao, M.V. (2016) Exercise promotes the expression of BDNF through the action of the ketone body hydroxylbutyrate. eLife pii: e15092. doi:10.7554/eLife.15092.

Kranz, T.M., Goetz, R.R., Walsh-Messinger, J., Goetz, D., Antonius, D., Dolgalev, I., Heguy, A., Seandel, M., Malaspina, D., Chao, M.V. (2015) Rare variants in the neurotrophin signaling pathway implicated in schizophrenia risk. Schizophr Res. pii: S0920-9964(15)00341-2. doi: 10.1016/j.schres.2015.07.002.

Bowling, H., Zhang, G., Bhatacharya, A., Perez-Cuesta, L.M., Deinhardt, K., Hoeffer, C.A., Neubert, T.A., Gan, W.B., Klann, E.  and Chao, M.V. (2014) Antipsychotics activate mTORC1-dependent translation to enhance neuronal morphological complexity. Science Signal. 7, (308) ra4, doi: 10.1126/scisignal.2004331.

Jeanneteau, F., Deinhardt, K., Miyoshi, G., Bennett, A.M. and Chao, M.V. (2010) The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching.  Nature Neurosci 13, 1373-1379.

Camarena, V., Kobayashi, M, Kim, J.Y., Roehm, P., Perez, R., Garner, J., Wilson, A.C., Mohr, I. and Chao, M.V. (2010) Nature   and duration of growth factor signaling through receptor tyrosine kinases regulates HSV latency in neurons.  Cell Host Microbe 8, 320-330.

Parkhurst, C.N., Zampieri, N. and Chao, M.V. (2010) Nuclear localization of the p75 neurotrophin receptor intracellular domain.  J. Biol. Chem. 285, 5361-5368.

Ninan, I., Bath, K.G., Dagar, K., Perez-Castro, R., Plummer, M.R., Lee, F.S. and Chao, M.V. (2010) The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus.  J Neuroscience 30, 8866 8870.

Savas, J.N., Ma, B., Deinhardt, K., Culver, B.P., Restituito, S., Wu. S., Belasco, J.G., Chao, M.V., Tanese, N. (2010). A role for Huntington disease protein in dendritic RNA granules.  J Biol Chem 285, 13142-13153.

Arevalo, J.C., Wu, S.H., Takahashi, T., Zhang, H., Yu, T., Yano, H., Milner, T.A., Tessarollo, L., Ninan, I., Arancio, O. and Chao,   M.V. (2010) The ARMS/Kidins220 scaffold protein modulates synaptic transmission.  Mol Cell Neurosci 45, 92-100.

Wu, S.H., Arevalo, J.C., Sarti, F., Tessarollo, L, Gan. W.B. and Chao, M.V. (2009) Ankryin repeat rich membrane spanning/Kidins220 protein regulates dendritic branching and spine stability in vivo.  Dev Neurobiology 69, 547-557.

Rosenbluth, J., Schiff, R., Lam, P., Nuriel, T. and Chao, M.V. (2009) Spongiform pathology in mouse CNS lacking ‘neuropathy target esterase’ and cellular prion protein.  Neurobiol Disease 35, 433-437.

Jeanneteau, F., Garabedian, M. and Chao, M.V. (2008) Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect.  Proc. Natl. Acad. Sci. 105, 4862-4867.

Domeniconi, M., Hempstead, B.L. and Chao, M.V. (2007) Pro-NGF secreted by astrocytes promotes motor neuron cell death. Mol. Cell. Neuroscience 34, 271-279.

Wiese, S., Jablonka, S., Holtmann, B., Orel, N., Rajagopal, R., Chao, M.V. and Sendtner, M. (2007) Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB.  Proc. Natl. Acad. Sci. 104, 17210-17215.

Arevalo, J.C., Pereira, D., Yano, H., Teng, K.K. and Chao, M.V. (2006) Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation, J. Biol Chem. 281, 1001-1007.

Arevalo, J.C., Waite, J., Rajagopal, R., Beyna, M., Chen, Z-Y., Lee, F.S. and Chao, M.V. (2006) Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron 50, 549-559.

Rajagopal, R. and Chao, M.V. (2006) A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling.  Mol. Cell. Neurosci 33, 36-46.

Yano, H., Ninan, I., Zhang, H., Milner, T.A., Arancio, O., Chao, M.V. (2006) BDNF-mediated neurotransmission relies upon a myosin VI motor complex.  Nature Neurosci 9, 1009-1018.

Zampieri, N., Xu, C., Neubert, T.A., Chao, M.V. (2005) Cleavage of p75 neurotrophin receptor by alpha secretase and gamma secretase requires specific receptor domains.  J Biol Chem 280, 14563-14571.

Arevalo, J.C., Yano, H., Teng, K.K., Chao, M.V. (2004) A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane spanning protein.  EMBO J 23, 2358-2368.

Rajagopal, R., Chen, Z-Y., Lee, F.S. and Chao, M.V. (2004) Transactivation of Trk neurotrophin receptors by G protein-coupled receptor ligands occurs on intracellular membranes.  J. Neuroscience 24, 6650-6658.

Akassoglou, K., Malester, B., Xu, J., Tessarollo, L., Rosenbluth, J. and Chao, M.V. (2004) Brain-specific deletion of Neuropathy Target Esterase/swisscheese results in neurodegeneration.  Proc Natl Acad Sci USA 101, 5075-5080.


Chao, M.V. (2019) Stoichiometry Counts.  Proc Natl Acad Sci 116, 21343-21345. Mitre, M., Minder, J., Morina, E.X., Chao, M.V., Froemke, R.C. (2018) Oxytocin modulation of neural circuits. Current Topics Behav Neurosci 35, 31-53.

Chao, M.V. (2016) Intercellular networks underlying developmental disorders. Neuron 91, 947-949.

Mariga, A., Mitre, M. and Chao, M.V. (2016) Consequences of brain-derived neurotrophic factor    withdrawal in CNS neurons and implications in disease. Neurobiology Disease 97, 73-79.

Scharfman, H.E. and Chao, M.V. (2013) The entorhinal cortex and neurotrophin signaling in Alzheimer’s disease and other disorders. Cognitive Neurosci 4, 123-135.

Deinhardt, K. and Chao, M.V. (2014) Shaping neurons: Long and short range effects of mature and proBDNF signaling upon neuronal structure. Neuropharmacology, doi: 10.1016/j.neuropharm.2013.04.054. Epub 2013

Chao, M.V. (2010) Increasing the specificity of neurotrophic factors.  Proc. Natl. Acad. Sci. 107, 13565 13566.

Chao, M.V. (2010).  A conversation with Rita Levi-Montalcini.  Interview by Moses V. Chao.  Ann. Review Physiology 72, 1-13. 135857?prevSearch=Rita%2BLevi-Montalcini&searchHistoryKey=

Arancio, O. and Chao, M.V. (2007) Neurotrophins, synaptic plasticity, and dementia. Current Opinion in Neurobiol. 17, 325-330.

Zampieri, N. and Chao, M.V. (2006) Mechanisms of neurotrophin receptor signaling.  Biochem. Soc. Trans. 34, 607-611.

Jeanneteau, F. and Chao, M.V. (2006) Promoting neurotrophic effects by GPCR ligands.  Novartis Found. Symp. 276, 181-189.

Chao, M.V., Rajagopal, R. and Lee, F.S. (2005) Neurotrophin signaling in health and disease.  Clinical Science 110, 167-173.

Chao, M.V. and Lee, F.S. (2004) Neurotrophin survival signaling mechanisms.  J Alzheimers Disease, S7-S11.

Zampieri, N. and Chao, M.V. (2004) The p75 NGF receptor exposed.  Science 304, 833-834.